Systems Immunogenetics of Biodefense in the Collaborative Cross

Gale Lab is partnering with Dr. Ralph Baric and Dr. Mark Heise of the University of North Carolina at Chapel Hill, and others, to develop new--genetically defined mouse models to mechanistically define the role of specific polymorphic genes and sets of genes in differentially regulating targeted immune responses.

Individual Research Projects

Project 1:  System Immunogenetics of SARS-CoV Infection
                   Dr. Ralph S. Baric, Professor Department of Epidemiology, UNC Chapel Hill

Project 2:  System Immunogenetics of Influenza-Induced Innate & Adaptive Immunity in the Lung
                   Dr. Mark Heise, Assistant Professor of Genetics, School of Medicine, UNC Institute for Global Health & Infectious Diseases

Project 3:  System Immunogenetics of Innate Immune and Inflammatory Responses to West Nile Virus Infection
                   Dr. Michael Gale, Jr.

Project 4:  System Immunogenetics of West Nile Virus Infection: Adaptive Immunity 
                   Dr. Jennifer Lund

Cores

Core A:  Administrative and Education Core
               Dr. Ralph S. Baric, Professor Department of Epidemiology, UNC Chapel Hill

Core B:  Animal Models Core
               Dr. Fernando Pardo-Manuel de Villena, Interim Chair, Professor, UNC Chapel Hill

Core C:  High-Throughput Molecular Profiling Core

Core D:  Systems Immunogenetics Core
               Dr. Shannon McWeeney, OHSU

Core E:  Bioinformatics Core