Submitted by galeadmin on Wed, 09/20/2017 - 21:02

The essential, nonredundant roles of RIG-I and MDA5 in detecting and controlling West Nile virus infection.

Errett JS, Suthar MS, McMillan A, Diamond MS, Gale M Jr.
J Virol. 2013 Nov;87(21):11416-25. doi: 10.1128/JVI.01488-13. Epub 2013 Aug 21. PMID: 23966395

Pattern recognition receptor MDA5 modulates CD8+ T cell-dependent clearance of West Nile virus from the central nervous system.

Lazear HM, Pinto AK, Ramos HJ, Vick SC, Shrestha B, Suthar MS, Gale M Jr, Diamond MS.
J Virol. 2013 Nov;87(21):11401-15. doi: 10.1128/JVI.01403-13. Epub 2013 Aug 21. PMID: 23966390

Regulation of hepatic innate immunity by hepatitis C virus.

Horner SM, Gale M Jr.
Nat Med. 2013 Jul;19(7):879-88. doi: 10.1038/nm.3253. Review. PMID: 23836238

A short hairpin RNA screen of interferon-stimulated genes identifies a novel negative regulator of the cellular antiviral response.

Li J, Ding SC, Cho H, Chung BC, Gale M Jr, Chanda SK, Diamond MS.
MBio. 2013 Jun 18;4(3):e00385-13. doi: 10.1128/mBio.00385-13. PMID: 23781071

Hepatitis C virus pathogen associated molecular pattern (PAMP) triggers production of lambda-interferons by human plasmacytoid dendritic cells.

Stone AE, Giugliano S, Schnell G, Cheng L, Leahy KF, Golden-Mason L, Gale M Jr, Rosen HR.
PLoS Pathog. 2013;9(4):e1003316. doi: 10.1371/journal.ppat.1003316. Epub 2013 Apr 18. Erratum in: PLoS Pathog. 2013 Jun;9(6). doi:10.1371/annotation/6382d059-925d-4af7-b6f2-3669fc68ddfa. PMID: 23637605

IL-1β production through the NLRP3 inflammasome by hepatic macrophages links hepatitis C virus infection with liver inflammation and disease.

Negash AA, Ramos HJ, Crochet N, Lau DT, Doehle B, Papic N, Delker DA, Jo J, Bertoletti A, Hagedorn CH, Gale M Jr.
PLoS Pathog. 2013;9(4):e1003330. doi: 10.1371/journal.ppat.1003330. Epub 2013 Apr 25. PMID: 23633957

A systems biology approach reveals that tissue tropism to West Nile virus is regulated by antiviral genes and innate immune cellular processes.

Suthar MS, Brassil MM, Blahnik G, McMillan A, Ramos HJ, Proll SC, Belisle SE, Katze MG, Gale M Jr.
PLoS Pathog. 2013 Feb;9(2):e1003168. doi: 10.1371/journal.ppat.1003168. Epub 2013 Feb 7. PMID: 23544010

Differential innate immune response programs in neuronal subtypes determine susceptibility to infection in the brain by positive-stranded RNA viruses.

Cho H, Proll SC, Szretter KJ, Katze MG, Gale M Jr, Diamond MS.
Nat Med. 2013 Apr;19(4):458-64. doi: 10.1038/nm.3108. Epub 2013 Mar 3. PMID: 23455712

RNA helicase signaling is critical for type i interferon production and protection against Rift Valley fever virus during mucosal challenge.

Ermler ME, Yerukhim E, Schriewer J, Schattgen S, Traylor Z, Wespiser AR, Caffrey DR, Chen ZJ, King CH, Gale M Jr, Colonna M, Fitzgerald KA, Buller RM, Hise AG.
J Virol. 2013 May;87(9):4846-60. doi: 10.1128/JVI.01997-12. Epub 2013 Feb 13. PMID: 23408632

Sterol-izing innate immunity.

Wilkins C, Gale M Jr.
Immunity. 2013 Jan 24;38(1):3-5. doi: 10.1016/j.immuni.2013.01.002. PMID: 23352217

West Nile virus infection and immunity.

Inflammasome adaptor protein Apoptosis-associated speck-like protein containing CARD (ASC) is critical for the immune response and survival in west Nile virus encephalitis.

Kumar M, Roe K, Orillo B, Muruve DA, Nerurkar VR, Gale M Jr, Verma S.
J Virol. 2013 Apr;87(7):3655-67. doi: 10.1128/JVI.02667-12. Epub 2013 Jan 9. PMID: 23302887

CD22 is required for protection against West Nile virus Infection.

Ma DY, Suthar MS, Kasahara S, Gale M Jr, Clark EA.
J Virol. 2013 Mar;87(6):3361-75. doi: 10.1128/JVI.02368-12. Epub 2013 Jan 9. PMID: 23302871

IRF-3, IRF-5, and IRF-7 coordinately regulate the type I IFN response in myeloid dendritic cells downstream of MAVS signaling.

Lazear HM, Lancaster A, Wilkins C, Suthar MS, Huang A, Vick SC, Clepper L, Thackray L, Brassil MM, Virgin HW, Nikolich-Zugich J, Moses AV, Gale M Jr, Früh K, Diamond MS.
PLoS Pathog. 2013 Jan;9(1):e1003118. doi: 10.1371/journal.ppat.1003118. Epub 2013 Jan 3. Erratum in: PLoS Pathog. 2013 May;9(5). :10.1371/annotation/4de7ddfd-52df-4f87-8ca4-d48afe646ca8. PMID: 23300459