NIH IMVC Program

Center for the Study of Immune Mechanisms of Flavivirus Control (IMVC)

The Center for the Study of Immune Mechanisms of Flavivirus Control is supported by the NIH and is comprised of 4 projects and two cores, integrated into a program of study aimed at defining the immune mechanisms that control West Nile virus infection. These unique projects feature comparative analyses of the emergent, virulent strain of WNV and a non-emergent, avirulent WNV strain. Results from these studies are providing novel insights to gu ide vaccine and therapeutic strategies aimed at modulating flavivirus infection.

  • Project 1:  Pathogen recognition and induction of innate immunity and inflammation against flavivirus infection
  • Administrative Core:  
    Dr. Michael Gale, Jr., Project Leader & Core Leader

 

 

  • Project 3:  Innate immune programming of humoral immunity to flaviviruses
  • Mouse Resources Core
    Dr. Edward Clark, Project Leader & Core Leader

 

  • Project 4:  RIG-I-like receptor regulation of T cell immunity against flavivirus infection
    Dr. Mehul Suthar, Project Leader