2020

Submitted by galeadmin on Tue, 02/04/2020 - 08:53

De novo design of potent and resilient hACE2 decoys to neutralize SARS-CoV-2

Linsky TW, Vergara R, Codina N, Nelson JW, Walker MJ, Su W, Barnes CO, Hsiang TY, Esser-Nobis K, Yu K, Reneer ZB, Hou YJ, Priya T, Mitsumoto M, Pong A, Lau UY, Mason ML, Chen J, Chen A, Berrocal T, Peng H, Clairmont NS, Castellanos J, Lin YR, Josephson-Day A, Baric RS, Fuller DH, Walkey CD, Ross TM, Swanson R, Bjorkman PJ, Gale M Jr, Blancas-Mejia LM, Yen HL, Silva DA..
Science . 2020 Nov 5:eabe0075. doi: 10.1126/science.abe0075. Online ahead of print. PMID: 33154107


New horizons in adjuvants for vaccine development

Reed SG, Tomai M, Gale MJ Jr.
Curr Opin Immunol. 2020 Oct 7;65:97-101. doi: 10.1016/j.coi.2020.08.008. Online ahead of print. PMID: 33038865


Cell type- and replication stage-specific influenza virus responses in vivo

Fay EJ, Aron SL, Macchietto MG, Markman MW, Esser-Nobis K, Gale M Jr, Shen S, Langlois RA.
PLoS Pathog. 2020 Aug 13;16(8):e1008760. doi: 10.1371/journal.ppat.1008760. eCollection 2020 Aug. PMID: 32790753


A Geroscience Approach to Preventing Pathologic Consequences of COVID-19

Dou Y, Fatemi S, Darvas M, Gale M Jr, Ladiges W.
J Interferon Cytokine Res. 2020 Sep;40(9):433-437. doi: 10.1089/jir.2020.29018.dou. Epub 2020 Aug 13. PMID: 32790488


Proteome-Wide Zika Virus CD4 T Cell Epitope and HLA Restriction Determination

Campbell VL, Nguyen L, Snoey E, McClurkan CL, Laing KJ, Dong L, Sette A, Lindestam Arlehamn CS, Altmann DM, Boyton RJ, Roby JA, Gale M Jr, Stone M, Busch MP, Norris PJ, Koelle DM.
Immunohorizons. 2020 Aug 4;4(8):444-453. doi: 10.4049/immunohorizons.2000068. PMID: 32753403


An Alphavirus-derived replicon RNA vaccine induces SARS-CoV-2 neutralizing antibody and T cell responses in mice and nonhuman primates

Erasmus JH, Khandhar AP, O'Connor MA, Walls AC, Hemann EA, Murapa P, Archer J, Leventhal S, Fuller JT, Lewis TB, Draves KE, Randall S, Guerriero KA, Duthie MS, Carter D, Reed SG, Hawman DW, Feldmann H, Gale M Jr, Veesler D, Berglund P, Fuller DH..
Sci Transl Med. 2020 Aug 5;12(555):eabc9396. doi: 10.1126/scitranslmed.abc9396. Epub 2020 Jul 20. PMID: 32690628


Spatiotemporal Dynamics of Innate Immune Signaling via RIG-I-like Receptors

Esser-Nobis K, Hatfield LD, Gale M Jr.
Proc Natl Acad Sci U S A. 2020 Jun 22;201921861. doi: 10.1073/pnas.1921861117. Online ahead of print.


Single-dose Replicating RNA Vaccine Induces Neutralizing Antibodies Against SARS-CoV-2 in Nonhuman Primates.

Erasmus JH, Khandhar AP, Walls AC, Hemann EA, O'Connor MA, Murapa P, Archer J, Leventhal S, Fuller J, Lewis T, Draves KE, Randall S, Guerriero KA, Duthie MS, Carter D, Reed SG, Hawman DW, Feldmann H, Gale M Jr, Veesler D, Berglund P, Fuller DH.
bioRxiv.. 2020 May 28:2020.05.28.121640. doi: 10.1101/2020.05.28.121640. Preprint. PMID: 32511417


The Early Local and Systemic Type I Interferon Responses to Ultraviolet B Light Exposure Are cGAS Dependent.

Skopelja-Gardner S, An J, Tai J, Tanaka L, Sun X, Hermanson P, Baum R, Kawasumi M, Green R, Gale M Jr, Kalus A, Werth VP, Elkon KB.
Sci Rep.. 2020 May 13;10(1):7908. doi: 10.1038/s41598-020-64865-w.


Systematic Profiling of Full-Length Ig and TCR Repertoire Diversity in Rhesus Macaque Through Long Read Transcriptome Sequencing.

Brochu HN, Tseng E, Smith E, Thomas MJ, Jones AM, Diveley KR, Law L, Hansen SG, Picker LJ, Gale M Jr, Peng X.
J Immunol. 2020 May 6;ji1901256. doi: 10.4049/jimmunol.1901256. Online ahead of print.


Innate Immunity in Hepatitis C Virus Infection.

Schwerk J, Negash A, Savan R, Gale M Jr.
Cold Spring Harb Perspect Med.. 2020 Apr 27;a036988. doi: 10.1101/cshperspect.a036988. Online ahead of print.


RIG-I-like Receptor Activation Drives Type I IFN and Antiviral Signaling to Limit Hantaan Orthohantavirus Replication.

Kell AM, Hemann EA, Turnbull JB, Gale M Jr.
PLoS Pathog. 2020 Apr 24;16(4):e1008483. doi: 10.1371/journal.ppat.1008483. eCollection 2020 Apr.


Flavivirus Nonstructural Protein NS5 Dysregulates HSP90 to Broadly Inhibit JAK/STAT Signaling.

Roby JA, Esser-Nobis K, Dewey-Verstelle EC, Fairgrieve MR, Schwerk J, Lu AY, Soveg FW, Hemann EA, Hatfield LD, Keller BC, Shapiro A, Forero A, Stencel-Baerenwald JE, Savan R, Gale M Jr.
Cell . 2020 Apr 7;9(4):899. doi: 10.3390/cells9040899.


Engagement of Monocytes, NK Cells, and CD4+ Th1 Cells by ALVAC-SIV Vaccination Results in a Decreased Risk of SIVmac251 Vaginal Acquisition.

Gorini G, Fourati S, Vaccari M, Rahman MA, Gordon SN, Brown DR, Law L, Chang J, Green R, Barrenäs F, Liyanage NPM, Doster MN, Schifanella L, Bissa M, Silva de Castro I, Washington-Parks R, Galli V, Fuller DH, Santra S, Agy M, Pal R, Palermo RE, Tomaras GD, Shen X, LaBranche CC, Montefiori DC, Venzon DJ, Trinh HV, Rao M, Gale M Jr, Sekaly RP, Franchini G.
PLoS Pathog . 2020 Mar 12;16(3):e1008377. doi: 10.1371/journal.ppat.1008377. eCollection 2020 Mar.


African Green Monkeys Avoid SIV Disease Progression by Preventing Intestinal Dysfunction and Maintaining Mucosal Barrier Integrity.

Raehtz KD, Barrenäs F, Xu C, Busman-Sahay K, Valentine A, Law L, Ma D, Policicchio BB, Wijewardana V, Brocca-Cofano E, Trichel A, Gale M Jr, Keele BF, Estes JD, Apetrei C, Pandrea I.
PLoS Pathog . 2020 Mar 2;16(3):e1008333. doi: 10.1371/journal.ppat.1008333. eCollection 2020 Mar.


Human DNA-PK activates a STING-independent DNA sensing pathway.

Burleigh K, Maltbaek JH, Cambier S, Green R, Gale M Jr, James RC, Stetson DB.
Sci Immunol.. 2020 Jan 24;5(43). pii: eaba4219. doi: 10.1126/sciimmunol.aba4219. PMID: 31980485