Gale Laboratory is part of the University of Washington, School of Medicine, Department of Immunology, and the Center for Innate Immunity and Immune Disease (CIIID). We are located at South Lake Union Campus.
Research in the Gale laboratory is focused on understanding the processes that trigger and control innate immunity and inflammation to program the immune response against RNA virus infection, and to define the virus-host interactions that control viral replication and the outcome of infection and immunity. We are also focused on defining the systems biology and innate immune interactions of chronic microbial infection.
The laboratory is a member of the CIIID and is a component of the Systems Immunogenics Consortium, the Immune Mechanisms of Protection Against Mycobacterium Tuberculosis (IMPAc-TB) consortium, and the Adjuvant Discovery and Development Program, each funded by the National Institutes of Health (NIH). The lab is also a component of the HIV Reservoir consortium supported by the Bill and Melinda Gates Foundation. The lab houses the NIH-funded Nonhuman Primate Functional Genomics Core for AIDS vaccine Development. Additionally, The Gale laboratory has active research programs focused on understanding immune control of infection by hepatitis C virus, hepatitis B viruses, flaviviruses including Zika virus and West Nile virus, Hanta virus, contemporary and emerging coronaviruses, and influenza viruses. We are also engaged in programs of study to understand the role of innate immunity in maternal-fetal health. Our research team is working at the forefront of innate immunity to understand the immunomodulatory/antiviral actions of interferons, and to develop small molecule innate immune agonists as antiviral mediators for the clinical treatment of virus infection. The lab works closely with collaborators in Seattle and across the globe to conduct vaccine research focused on developing new vaccines for HIV, Yellow Fever virus, West Nile virus, Zika virus, hepatitis B virus, and influenza A virus. The lab is a component of the UW Center for Emerging and Re-emerging Infectious Diseases (CERID) to isolate and study novel emerging RNA viruses. We are committed to teaching and training scientists to be educators, researchers, and clinicians in the areas of immunology, virology, public and global health, systems biology, and microbial infection and immunity.