Gale Laboratory is part of the University of Washington, School of Medicine in the Department of Immunology. We are located at South Lake Union Campus.
Research in the Gale laboratory is focused on understanding innate immunity to RNA virus infection, and the intracellular immune processes and virus-host interactions that govern viral replication, the immune response to infection, viral pathogenesis, and the overall outcome of infection. The laboratory is a member of the new Center Innate Immunity and Immune Disease, and is a component of the Hepatitis C virus (HCV) Cooperative Research Centers, as well as the Immune Mechanisms of Virus Control program, both supported by the NIH. Additionally, the Gale laboratory has research programs focused on understanding immune control of flavivirus infection, HIV, HIV/HCV coinfection, Hanta virus, contemporary and emerging coronaviruses, influenza viruses, and the immunomodulatory/antiviral actions of interferons and small molecule innate immune agonists as antiviral mediators of virus infection. The lab also conducts vaccine research focused on developing innate immune agonists as adjuvants for pairing with vaccines against high path influenza virus (bird flu), HIV, HCV, and other contemporary or emerging RNA viruses.