Recent Publications

Versican is Produced by Trif- and Type I Interferon-Dependent Signaling in Macrophages and Contributes to Fine-Control of Innate Immunity in Lungs.

Chang MY, Kang I, Gale M Jr, Manicone AM, Kinsella MG, Braun KR, Wigmosta T, Parks WC, Altemeier WA, Wight TN, Frevert CW.
Am J Physiol Lung Cell Mol Physiol. 2017 Sep 14:ajplung.00353.2017.  PMID: 28912382


RNA PAMPs as Molecular Tools for Evaluating RIG-I Function in Innate Immunity.

Ireton RC, Wilkins C, Gale M Jr.
Methods Mol Biol. 2017;1656:119-129.  PMID: 28808965


Oas1b-dependent Immune Transcriptional Profiles of West Nile Virus Infection in the Collaborative Cross.

Green R, Wilkins C, Thomas S, Sekine A, Hendrick DM, Voss K, Ireton RC, Mooney M, Go JT, Choonoo G, Jeng S, de Villena FP, Ferris MT, McWeeney S, Gale M Jr.
Nat. Immunology. 2017 Jun 7;7(6):1665-1682. PMID: 2859264


The A946T variant of the RNA sensor IFIH1 mediates an interferon program that limits viral infection but increases the risk for autoimmunity.

Gorman JA, Hundhausen C, Errett JS, Stone AE, Allenspach EJ, Ge Y, Arkatkar T, Clough C, Dai X, Khim S, Pestal K, Liggitt D, Cerosaletti K, Stetson DB, James RG, Oukka M, Concannon P, Gale M Jr, Buckner JH, Rawlings DJ.
Nat Immunol. 2017 Jul;18(7):744-752. PMID: 28553952


RIPK3 Restricts Viral Pathogenesis via Cell Death-Independent Neuroinflammation.

Daniels BP, Snyder AG, Olsen TM, Orozco S, Oguin TH 3rd, Tait SW, Martinez J, Gale M Jr, Loo YM, Oberst A.
Cell. 2017 Apr 6;169(2):301-313.e11.  PMID: 28366204


A small-molecule IRF3 agonist functions as an influenza vaccine adjuvant by modulating the antiviral immune response.

Probst P, Grigg JB, Wang M, Muñoz E, Loo YM, Ireton RC, Gale M Jr, Iadonato SP, Bedard KM.
Vaccine. 2017 Apr 4;35(15):1964-1971.  PMID: 28279563


Regional astrocyte IFN signaling restricts pathogenesis during neurotropic viral infection.

Daniels BP, Jujjavarapu H, Durrant DM, Williams JL, Green RR, White JP, Lazear HM, Gale M Jr, Diamond MS, Klein RS.
J Clin Invest. 2017 Mar 1;127(3):843-856. PMID: 28134626


MLKL Activation Triggers NLRP3-Mediated Processing and Release of IL-1β Independently of Gasdermin-D.

Gutierrez KD, Davis MA, Daniels BP, Olsen TM, Ralli-Jain P, Tait SW, Gale M Jr, Oberst A.
J Immunol. 2017 Mar 1;198(5):2156-2164.  PMID: 28130493


MAVS Is Essential for Primary CD4+ T Cell Immunity but Not for Recall T Cell Responses following an Attenuated West Nile Virus Infection.

Luo H, Winkelmann E, Xie G, Fang R, Peng BH, Li L, Lazear HM, Paessler S, Diamond MS, Gale M Jr, Barrett AD, Wang T.
J Virol. v.91(6). Print 2017 Mar 15. PMID: 28077630


Correction: Hepatitis C Virus Sensing by Human Trophoblasts Induces Innate Immune Responses and Recruitment of Maternal NK Cells: Potential Implications for Limiting Vertical Transmission.

Giugliano S, Petroff MG, Warren BD, Jasti S, Linscheid C, Ward A, Kramer A, Dobrinskikh E, Sheiko MA, Gale M Jr, Golden-Mason L, Winn VD, Rosen HR.
J Immunol. 2017 Jan 15;198(2):972. No abstract available. PMID: 28069758


RNA-Seq in the Collaborative Cross.

Green R, Wilkins C, Ferris MT, Gale M Jr.
Methods Mol Biol. 2017;1488:251-263. PMID: 27933528