We are collaborating with local and international colleagues in the response to the SARS-CoV-2 pandemic. These activities include directing the laboratory analysis to assess the efficacy of the Moderna vaccine across clinical trials in efforts that have now facilitated the US FDA and CDC approval of this vaccine for emergency use to vaccinate the American population and international populations.
We have also:
The Gale lab has been named on the annual Highly Cited Researchers 2020 list from Clarivate, and among the top 1% of all cited research teams in the in the World across the fields of innate immunity and microbiology. The Gale lab is joined by more than 50 other research groups at the University of Washington as leaders in their fields.
Dynamics of RIG-I-like receptor innate immune signaling regulation defined in a new study led by Dr. Katherina Esser-Nobis
Esser-Nobis K, Hatfield LD, Gale M Jr.Proc Natl Acad Sci U S A. 2020 Jun 22:201921861. doi: 10.1073/pnas.1921861117. Online ahead of print. PMID: 32571931
Roby JA, Esser-Nobis K, Dewey-Verstelle EC, Fairgrieve MR, Schwerk J, Lu AY, Soveg FW, Hemann EA, Hatfield LD, Keller BC, Shapiro A, Forero A, Stencel-Baerenwald JE, Savan R, Gale M Jr.
NEWS RELEASE from UW Medicine Newsroom
Caleb Stokes, MD, PhD. Has been awarded a K08 grant from NIH/NIAID to support the development of his independent research program defining the processes of innate immunity that control virus infection in the central nervous system. Focusing on Zika virus infection in human induced neural progenitor cells, his K08 award work aims to determine how innate immunity directs the outcome Zika virus infection in the developing brain.
New paper from the lab describing a study led by Dr. Alison Kell shows that Hantavirus triggers innate immune actions in part through RLR signaling to differentially control virus in models of reservoir versus non-reservoir hosts.
This research has implications for disease following zoonotic virus transmission, and importantly points to additional, non-RLR innate immune programs impacting innate immunity against Hantaviruses across hosts. Link to paper: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1008483
Data Stories | Understanding STING
See how researcher Kathryn McGuckin Wuertz is trying to understand the relationship between infectious diseases and neurological diseases
Kathryn McGuckin Wuertz is trying to understand the relationship between infectious diseases and neurological diseases. McGuckin Wuertz is a Major in the U.S. Army stationed at Walter Reed Army Institute of Research in Maryland.
Influenza virus infection causes significant illness and death globally each year despite the existence of a vaccine. Our work has sought to understand the innate immune determinates that are able to regulate the induction of protective adaptive immune responses against influenza in order to inform novel therapeutic and adjuvant strategies. We recently published a study revealing that the innate immune cytokine IFN-lambda acts on DC and is required for generation of optimal CD8 T cell-mediated protection against influenza virus infection in a murine model (DOI:10.1038/s41590-019-0408-z).