2012

IL-1β signaling promotes CNS-intrinsic immune control of West Nile virus infection.

Ramos HJ, Lanteri MC, Blahnik G, Negash A, Suthar MS, Brassil MM, Sodhi K, Treuting PM, Busch MP, Norris PJ, Gale M Jr.
PLoS Pathog. 2012;8(11):e1003039. doi: 10.1371/journal.ppat.1003039. Epub 2012 Nov 29. PMID: 23209411


Inhibition of cellular autophagy deranges dengue virion maturation.

Mateo R, Nagamine CM, Spagnolo J, Méndez E, Rahe M, Gale M Jr, Yuan J, Kirkegaard K.
J Virol. 2013 Feb;87(3):1312-21. doi: 10.1128/JVI.02177-12. Epub 2012 Nov 21. PMID:23175363


Innate immune tolerance and the role of kupffer cells in differential responses to interferon therapy among patients with HCV genotype 1 infection.

Lau DT, Negash A, Chen J, Crochet N, Sinha M, Zhang Y, Guedj J, Holder S, Saito T, Lemon SM, Luxon BA, Perelson AS, Gale M Jr.
Gastroenterology. 2013 Feb;144(2):402-413.e12. doi: 10.1053/j.gastro.2012.10.044. Epub 2012 Nov 2. PMID: 23123437


An attenuating mutation in a neurovirulent Sindbis virus strain interacts with the IPS-1 signaling pathway in vivo.

Wollish AC, Ferris MT, Blevins LK, Loo YM, Gale M Jr, Heise MT.
Virology. 2013 Jan 20;435(2):269-80. doi: 10.1016/j.virol.2012.09.008. Epub 2012 Oct 17. PMID: 23084425

IFITM1 is a tight junction protein that inhibits hepatitis C virus entry.

Wilkins C, Woodward J, Lau DT, Barnes A, Joyce M, McFarlane N, McKeating JA, Tyrrell DL, Gale M Jr.
Hepatology. 2013 Feb;57(2):461-9. doi: 10.1002/hep.26066. Epub 2012 Dec 12. PMID: 22996292

Thymic stromal lymphopoietin is induced by respiratory syncytial virus-infected airway epithelial cells and promotes a type 2 response to infection.

Lee HC, Headley MB, Loo YM, Berlin A, Gale M Jr, Debley JS, Lukacs NW, Ziegler SF.
J Allergy Clin Immunol. 2012 Nov;130(5):1187-1196.e5. doi: 10.1016/j.jaci.2012.07.031. Epub 2012 Sep 13. PMID: 22981788

Uridine composition of the poly-U/UC tract of HCV RNA defines non-self recognition by RIG-I.

Schnell G, Loo YM, Marcotrigiano J, Gale M Jr.
PLoS Pathog. 2012;8(8):e1002839. doi: 10.1371/journal.ppat.1002839. Epub 2012 Aug 2. PMID: 22912574

Systems biology analyses to define host responses to HCV infection and therapy.

Ireton RC, Gale M Jr.
Curr Top Microbiol Immunol. 2013;363:143-67. doi: 10.1007/82_2012_251. Review. PMID: 22903567

The RIG-I-like receptor LGP2 controls CD8(+) T cell survival and fitness.

Suthar MS, Ramos HJ, Brassil MM, Netland J, Chappell CP, Blahnik G, McMillan A, Diamond MS, Clark EA, Bevan MJ, Gale M Jr.
Immunity. 2012 Aug 24;37(2):235-48. doi: 10.1016/j.immuni.2012.07.004. Epub 2012 Jul 26. PMID: 22841161

LGP2 downregulates interferon production during infection with seasonal human influenza A viruses that activate interferon regulatory factor 3.

Malur M, Gale M Jr, Krug RM.
J Virol. 2012 Oct;86(19):10733-8. doi: 10.1128/JVI.00510-12. Epub 2012 Jul 25. PMID: 22837208

Interferon response factors 3 and 7 protect against Chikungunya virus hemorrhagic fever and shock.

Rudd PA, Wilson J, Gardner J, Larcher T, Babarit C, Le TT, Anraku I, Kumagai Y, Loo YM, Gale M Jr, Akira S, Khromykh AA, Suhrbier A.
J Virol. 2012 Sep;86(18):9888-98. doi: 10.1128/JVI.00956-12. Epub 2012 Jul 3. PMID: 22761364

Cell-intrinsic innate immune control of West Nile virus infection.

Diamond MS, Gale M Jr.
Trends Immunol. 2012 Oct;33(10):522-30. doi: 10.1016/j.it.2012.05.008. Epub 2012 Jun 20. Review. PMID: 22726607

Two new monoclonal antibodies for biochemical and flow cytometric analyses of human interferon regulatory factor-3 activation, turnover, and depletion.

Rustagi A, Doehle BP, McElrath MJ, Gale M Jr.
Methods. 2013 Feb;59(2):225-32. doi: 10.1016/j.ymeth.2012.05.011. Epub 2012 Jun 13. PMID: 22705311

Vpu-deficient HIV strains stimulate innate immune signaling responses in target cells.

Doehle BP, Chang K, Fleming L, McNevin J, Hladik F, McElrath MJ, Gale M Jr.
J Virol. 2012 Aug;86(16):8499-506. doi: 10.1128/JVI.00424-12. Epub 2012 May 30. PMID: 22647704

The mitochondrial targeting chaperone 14-3-3ε regulates a RIG-I translocon that mediates membrane association and innate antiviral immunity.

Liu HM, Loo YM, Horner SM, Zornetzer GA, Katze MG, Gale M Jr.
Cell Host Microbe. 2012 May 17;11(5):528-37. doi: 10.1016/j.chom.2012.04.006. PMID: 22607805

Vpu mediates depletion of interferon regulatory factor 3 during HIV infection by a lysosome-dependent mechanism.

2'-O methylation of the viral mRNA cap by West Nile virus evades ifit1-dependent and -independent mechanisms of host restriction in vivo.

Szretter KJ, Daniels BP, Cho H, Gainey MD, Yokoyama WM, Gale M Jr, Virgin HW, Klein RS, Sen GC, Diamond MS.
PLoS Pathog. 2012;8(5):e1002698. doi: 10.1371/journal.ppat.1002698. Epub 2012 May 10. PMID: 22589727

Infectious clones of novel lineage 1 and lineage 2 West Nile virus strains WNV-TX02 and WNV-Madagascar.

Suthar MS, Brassil MM, Blahnik G, Gale M Jr.
J Virol. 2012 Jul;86(14):7704-9. doi: 10.1128/JVI.00401-12. Epub 2012 May 9. PMID: 22573862

Isoflavone agonists of IRF-3 dependent signaling have antiviral activity against RNA viruses.

Bedard KM, Wang ML, Proll SC, Loo YM, Katze MG, Gale M Jr, Iadonato SP.
J Virol. 2012 Jul;86(13):7334-44. doi: 10.1128/JVI.06867-11. Epub 2012 Apr 24. PMID: 22532686

Convergent evolution of escape from hepaciviral antagonism in primates.

Patel MR, Loo YM, Horner SM, Gale M Jr, Malik HS.
PLoS Biol. 2012;10(3):e1001282. doi: 10.1371/journal.pbio.1001282. Epub 2012 Mar 13. PMID: 22427742

Autoimmunity initiates in nonhematopoietic cells and progresses via lymphocytes in an interferon-dependent autoimmune disease.

Gall A, Treuting P, Elkon KB, Loo YM, Gale M Jr, Barber GN, Stetson DB.
Immunity. 2012 Jan 27;36(1):120-31. doi: 10.1016/j.immuni.2011.11.018. PMID: 22284419

Control of innate immune signaling and membrane targeting by the Hepatitis C virus NS3/4A protease are governed by the NS3 helix α0.

Horner SM, Park HS, Gale M Jr.
J Virol. 2012 Mar;86(6):3112-20. doi: 10.1128/JVI.06727-11. Epub 2012 Jan 11. PMID: 22238314

A summary of the 18th International Symposium on Hepatitis C Virus and Related Viruses.

Polyak SJ, Morishima C, Scott JD, Gastaminza P, Cox A, de Araújo ES, Higgs MR, Loo YM, Golden-Mason L, Lindenbach BD, Baumert TF, Randall G, Gale M Jr.
Gastroenterology. 2012 Jan;142(1):e1-5. doi: 10.1053/j.gastro.2011.11.002. No abstract available. Erratum in: Gastroenterology. 2012 Feb;142(2):411. Gastaminza, Pablo [added]. PMID: 22185796

Dynamics of innate immunity are key to chronic immune activation in AIDS.

Benecke A, Gale M Jr, Katze MG.
Curr Opin HIV AIDS. 2012 Jan;7(1):79-85. doi: 10.1097/COH.0b013e32834dde31. Review. PMID: 22156845