2015

Membrane Perturbation-Associated Ca2+ Signaling and Incoming Genome Sensing Are Required for the Host Response to Low-Level Enveloped Virus Particle Entry.

Hare DN, Collins SE, Mukherjee S, Loo YM, Gale M Jr, Janssen LJ, Mossman KL.
J Virol. 2015 Dec 30;90(6):3018-27.  PMID: 26719279

SnapShot: Interferon Signaling.

Chow KT, Gale M Jr.
Cell. 2015 Dec 17;163(7):1808-1808.e1.  PMID: 26687364

Targeting Innate Immunity for Antiviral Therapy through Small Molecule Agonists of the RLR Pathway.

Pattabhi S, Wilkins CR, Dong R, Knoll ML, Posakony J, Kaiser S, Mire CE, Wang ML, Ireton RC, Geisbert TW, Bedard KM, Iadonato SP, Loo YM, Gale M Jr.
J Virol. 2015 Dec 16;90(5):2372-87.  PMID: 26676770

Identification of a Natural Viral RNA Motif That Optimizes Sensing of Viral RNA by RIG-I.

Xu J, Mercado-López X, Grier JT, Kim WK, Chun LF, Irvine EB, Del Toro Duany Y, Kell A, Hur S, Gale M Jr, Raj A, López CB.
MBio. 2015 Oct 6;6(5):e01265-15. PMID: 26443454

RIG-I Signaling Is Essential for Influenza B Virus-Induced Rapid Interferon Gene Expression.

Mäkelä SM, Österlund P, Westenius V, Latvala S, Diamond MS, Gale M Jr, Julkunen I.
J Virol. 2015 Dec;89(23):12014-25. PMID: 26378160

Class A Scavenger Receptor-Mediated Double-Stranded RNA Internalization Is Independent of Innate Antiviral Signaling and Does Not Require Phosphatidylinositol 3-Kinase Activity.

Nellimarla S, Baid K, Loo YM, Gale M Jr, Bowdish DM, Mossman KL.
J Immunol. 2015 Oct 15;195(8):3858-65.  PMID: 26363049

Hepatitis C Virus Sensing by Human Trophoblasts Induces Innate Immune Responses and Recruitment of Maternal NK Cells: Potential Implications for Limiting Vertical Transmission.

Giugliano S, Petroff MG, Warren BD, Jasti S, Linscheid C, Ward A, Kramer A, Dobrinskikh E, Sheiko MA, Gale M Jr, Golden-Mason L, Winn VD, Rosen HR.
J Immunol. 2015 Oct 15;195(8):3737-47.  PMID: 26342030

Pathogen-Associated Molecular Pattern Recognition of Hepatitis C Virus Transmitted/Founder Variants by RIG-I Is Dependent on U-Core Length.

Kell A, Stoddard M, Li H, Marcotrigiano J, Shaw GM, Gale M Jr.
J Virol. 2015 Nov;89(21):11056-68.  PMID: 26311867

Interference with Virus Infection.

Gale M Jr.
J Immunol. 2015 Sep 1;195(5):1909-10.  No abstract available. PMID: 26297789

Editorial overview: Antiviral strategies.

Gale M Jr, Horvath CM.
Curr Opin Virol. 2015 Jun;12:v-vii.  No abstract available. PMID: 26004174

Innate immunity against HIV-1 infection.

Altfeld M, Gale M Jr.
Nat Immunol. 2015 Jun;16(6):554-62. PMID: 25988887

Genetic diversity in the collaborative cross model recapitulates human West Nile virus disease outcomes.

Graham JB, Thomas S, Swarts J, McMillan AA, Ferris MT, Suthar MS, Treuting PM, Ireton R, Gale M Jr, Lund JM.
MBio. 2015 May 5;6(3):e00493-15. PMID: 25944860

Interferon-λ restricts West Nile virus neuroinvasion by tightening the blood-brain barrier.

Lazear HM, Daniels BP, Pinto AK, Huang AC, Vick SC, Doyle SE, Gale M Jr, Klein RS, Diamond MS.
Sci Transl Med. 2015 Apr 22;7(284):284ra59.  PMID: 25904743

Hepatitis regulation by the inflammasome signaling pathway.

Negash AA, Gale M Jr.
Immunol Rev. 2015 May;265(1):143-55.  PMID: 25879290

RNase L activates the NLRP3 inflammasome during viral infections.

Chakrabarti A, Banerjee S, Franchi L, Loo YM, Gale M Jr, Núñez G, Silverman RH.
Cell Host Microbe. 2015 Apr 8;17(4):466-77. PMID: 25816776

RIG-I in RNA virus recognition.

Kell AM, Gale M Jr.
Virology. 2015 May;479-480:110-21.  PMID: 25749629

Proteomic analysis of mitochondrial-associated ER membranes (MAM) during RNA virus infection reveals dynamic changes in protein and organelle trafficking.

Horner SM, Wilkins C, Badil S, Iskarpatyoti J, Gale M Jr.
PLoS One. 2015 Mar 3;10(3):e0117963.  PMID: 25734423

Hepatitis C virus infection induces autocrine interferon signaling by human liver endothelial cells and release of exosomes, which inhibits viral replication.

Giugliano S, Kriss M, Golden-Mason L, Dobrinskikh E, Stone AE, Soto-Gutierrez A, Mitchell A, Khetani SR, Yamane D, Stoddard M, Li H, Shaw GM, Edwards MG, Lemon SM, Gale M Jr, Shah VH, Rosen HR.
Gastroenterology. 2015 Feb;148(2):392-402.e13.  PMID: 25447848