A Small Molecule RIG-I Agonist Serves as an Adjuvant to Induce Broad Multifaceted Influenza Virus Vaccine Immunity

Targeting RIG-I with small molecules for induction of innate immunity enhances influenza A virus vaccine immunity including heterologous immunity against multiple viral HA types. This study reveals RIG-I as a valid drug target for strategies to effectively enhance broad spectrum antiviral immunity against virus infection. 

Read the study: https://pubmed.ncbi.nlm.nih.gov/36939421/