SARS-CoV-2 and COVID-19

Submitted by galeadmin on Tue, 05/26/2020 - 12:21

The Gale Laboratory is actively engaged in the local and national response to SARS-CoV-2 infection and COVID-19 disease, and is collaborating with our international colleagues to support the global response to control and prevent SARS-CoV-2 infection. Our efforts include conducting antibody testing to determine community exposure frequency to SARS-CoV-2, assessing SARS-CoV-2 infection and virus replication in culture, and defining the innate immune and inflammatory programs that are triggered and regulated by SARS-CoV-2 infection to impart COVID-19 disease outcome.

For updates on local and global COVID-19 status, the following resources are available:

Our response to COVID-19 and the SARS-CoV-2 pandemic

Submitted by galeadmin on Tue, 01/12/2021 - 17:18

We are collaborating with local and international colleagues in the response to the SARS-CoV-2 pandemic. These activities include directing the laboratory analysis to assess the efficacy of the Moderna vaccine across clinical trials in efforts that have now facilitated the US FDA and CDC approval of this vaccine for emergency use to vaccinate the American population and international populations.  

We have also:

The Gale lab has been named on the annual Highly Cited Researchers 2020 list from Clarivate.

Submitted by galeadmin on Fri, 11/20/2020 - 09:40

The Gale lab has been named on the annual Highly Cited Researchers 2020 list from Clarivate, and among the top 1% of all cited research teams in the in the World across the fields of innate immunity and microbiology.   The Gale lab is joined by more than 50 other research groups at the University of Washington as leaders in their fields.

Dr. Caleb Stokes awarded NIAID Clinical Scientist Research Career Development K08 Award.

Submitted by galeadmin on Fri, 05/22/2020 - 12:55

Caleb Stokes, MD, PhD. Has been awarded a K08 grant from NIH/NIAID to support the development of his independent research program defining the processes of innate immunity that control virus infection in the central nervous system. Focusing on Zika virus infection in human induced neural progenitor cells, his K08 award work aims to determine how innate immunity directs the outcome Zika virus infection in the developing brain.

Dr. Katherine Wuertz completes her dissertation and returns to the US Army as Major

Submitted by galeadmin on Thu, 04/02/2020 - 12:06

Data Stories | Understanding STING

See how researcher Kathryn McGuckin Wuertz is trying to understand the relationship between infectious diseases and neurological diseases

Kathryn McGuckin Wuertz is trying to understand the relationship between infectious diseases and neurological diseases. McGuckin Wuertz is a Major in the U.S. Army stationed at Walter Reed Army Institute of Research in Maryland.

Dr. Hemann has been awarded an NIAID K22 career transition award

Submitted by galeadmin on Fri, 03/06/2020 - 09:36

Influenza virus infection causes significant illness and death globally each year despite the existence of a vaccine. Our work has sought to understand the innate immune determinates that are able to regulate the induction of protective adaptive immune responses against influenza in order to inform novel therapeutic and adjuvant strategies. We recently published a study revealing that the innate immune cytokine IFN-lambda acts on DC and is required for generation of optimal CD8 T cell-mediated protection against influenza virus infection in a murine model (DOI:10.1038/s41590-019-0408-z).

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